Tibolone Trenbolone Steroid Powder Tibolon Anti Aging for
Sorage:Store below 25ºC but not in the fridge.
Therapeutic Categories:Hormone replacement therapy (HRT).Synthetic steroid with partial estrogenic, progestagenic and
Tibolone possesses a complex pharmacology. Its two major active
metabolites, 3α-hydroxytibolone and 3β-hydroxytibolone, act as
potent, fully activating agonists of the estrogen receptor (ER),
with a high preference for ERα. Tibolone and its metabolite Δ4-tibolone act as agonists of the progesterone and androgen
receptors,while 3α-hydroxytibolone and 3β-hydroxytibolone,
conversely, act as antagonists of these receptors.
Lastly, tibolone, 3α-hydroxytibolone, and 3β-hydroxytibolone act as
antagonists of the glucocorticoid and mineralocorticoid receptors,
with preference for the mineralocorticoid receptor.Tibolone has tissue-selective estrogenic effects, with desirable
effects in bone, the brain, and the vagina, and lack of undesirable
action in the endometrium and breasts.
Its tissue selectivity is the result of metabolism, enzyme
modulation (e.g., of estrogen sulfatase and estrogen
sulfotransferase), and receptor modulation that vary in different
target tissues, and differs mechanistically from that of selective
estrogen receptor modulators (SERMs) such as tamoxifen, which
produce their tissue-selectivity via means of modulation of the ER.
As such, to distinguish it from SERMs, tibolone has been described
as a "selective tissue estrogenic activity regulator" (STEAR),and
also as a "selective estrogen enzyme modulator" (SEEM).
A report in September 2009 from Health and Human Services' Agency
for Healthcare Research and Quality suggests that tamoxifen,
raloxifene, and tibolone used to treat breast cancer significantly
reduce invasive breast cancer in midlife and older women, but also
increase the risk of adverse side effects.
|Product Name||Tibolone Acetate Powder|
|CAS Registry Number||5630-53-5|
|Appearance||white crystalline powder|
Symptoms of overdose include feeling sick or being sick and vaginal
If you think you, or someone you care for, might have accidentally
taken more than the recommended dose of tibolone or intentional
overdose is suspected, contact your local hospital, GP or if in
England call 111. In Scotland call NHS 24. In Wales, call NHS
Direct Wales. In the case of medical emergencies, always dial 999.
If you miss a dose, take it as soon as you remember, unless you are
more than 12 hours late. If you are more than 12 hours late, skip
the missed dose and resume your usual dosing schedule. Do not
double the dose to catch up